Document Type : Original Article

Authors

• Olumakinde Charles Omiyale ¹
• Dorcas Atanda ²
• Daniel Ebubechi Obasi ³
• Fawaz Isshak ⁴
• Anthony Nduka Kokelu ⁵
• Obinna Kenneth Didigwu ⁶
• Surajudeen Adewumi Adeyemi ⁷
• Blessing Chinyere Amamba ⁸
• Taiwo Toyobo ⁹
• Oluwaseun Nneka Oni-Adimabua ¹⁰
• Victoria Biola Edema ¹¹
• Pelumi Habeeb Fagbenro ¹²

¹ Department of Pharmacology, Toxicology and Therapeutics, College of Medicine, University of Lagos, 101014, Nigeria

² Department of Biochemistry, Faculty of Life Sciences, Lagos State University, Lagos, 102101, Nigeria

³ Department of Medicine and Surgery, Faculty of Clinical Sciences, University of Ibadan, Oyo State, Nigeria

⁴ Department of Food Science and Technology, Kwame Nkrumah University of Science and Technology, Ghana

⁵ Department of Human Physiology, University of Calabar, Cross River State, Nigeria

⁶ Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria Nsukka, 410001 Enugu State, Nigeria

⁷ Department of Chemical Science, Faculty of Basic and Applied Sciences, Osun State University Osogbo, Osun State, Nigeria

⁸ Department of Biochemistry, Faculty of Basic Medical Science, University of Ibadan, Oyo state, Nigeria

⁹ Department of Biochemistry, Nutritional and Industrial Biochemistry Unit, University of Ibadan, Ibadan, Oyo state, Nigeria

¹⁰ Department of Science Laboratory Technology, Faculty of Clinical Sciences, Red River Polytech College, Winnipeg, Canada

¹¹ Department of Physiology, Faculty of Science, Olabisi Onabanjo University, Nigeria

¹² Department of Biochemistry, Faculty of Science, Lagos State University, Nigeria

Abstract

One of the most significant seeds crops in the world, Sorghum bicolor, is recognized for its vibrant phytochemicals, which may have medicinal uses. The aim of this study is to determine the antioxidant and hypoglycemic properties of Sorghum bicolor seeds. The ethanol and methanol extracts of these plants were subjected to antidiabetic conditioning using methods such as glucose adsorption capacity, muscle glucose uptake, and yeast glucose uptake, while iron-sulphate and sodium nitroprusside-induced lipid peroxidation were used to analyse the antioxidant capabilities. The results demonstrate that Sorghum bicolor's ethanol and methanol extracts adsorbed glucose, with the concentration of glucose adsorption rising as extract concentrations did. The muscle glucose uptake levels and glucose adsorption capabilities differed significantly (p ≤0.05). The yeast cells' ability to absorb glucose was likewise enhanced by the plant extracts, and glucose uptake was measured. In the brain and liver of iron-sulfurate-induced lipid peroxidation, the MDA (malondialdehyde) product was considerably (p ≤0.05) elevated. However, there was no significant change in the MDA product of sodium nitroprusside-induced lipid peroxidation. The ethanol and methanol extracts of Sorghum bicolor were found to have further potential as antioxidant and anti-glycemic agents, respectively, in this study.

Graphical Abstract

Keywords

• Sorghum bicolor
• Antioxidant
• Hypoglycemic
• Lipid peroxidation

Main Subjects

• Analytical Chemistry

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