Document Type : Original Article
Authors
- Saman Ayoubi 1
- Mohammad Sadegh Hashemzadeh 2
- Omid Lakzaie Azar 3
- Fatemeh Naeimpour 4
- Nasim Padasht 5
- Bashir Mirtajani 5
- Jafar Aghajani 5
- Mahdi Tat 2
- Mojtaba Sharti 2
- Ruhollah Dorostkar 2
1 Mycobacteriology Research Centre, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
3 fajr Milk, Industry Co., Golestan Sabah, Sabah, Gonbad, Iran
4 Department of Mycology, Fac of Vet. Med, Science and Research Branch Of Islamic Azad University, Tehran, Iran
5 Department of biotechnology, Faculty of Basic Sciences, Lahijan Branch, Islamic Azad University (IAU), Lahijan, Iran
Abstract
Human T-cell lymphotropic virus type 1 , 2 (HTLV-1, 2) is endemic in Particular Areas of the world in which it is associated with myeloid leukemia.In this study, we described the prevalence of HTLV-1, 2 in myeloid leukemia and Mycobacterium Tuberculosis in Iran. We have worked with tissue and blood samples for 2 years. These were the same samples which were positive for myeloid leukemia, Mycobacterium tuberculosis,HTLV and were collected from Imam Khomeini hospital in Tehran, Iran. 100 cases were investigated (58% males, 42% females), the age of these samples were within 5 to 89 years old.In 65.7 percent of the leukemia rate HTLV-1 has been positive. Five cases (54%) were myeloid leukemia, 36.4% cases were not myeloid leukemia and 3 out of 8 cases (27.9%) unclassified lymphomas, were positive respectively. All 6 cases (100%) were adults with acute T-cell leukemia/lymphoma (ATLL) and Mycobacterium tuberculosis were positive. Among all cases, just one case has been positive for chronic myeloid leukemia and myeloproliferative disruption. Positive HTLV-1- show more in older ages than younger one. At younger ages offers less than negative items. According to our results, in Iran HTLV-1, 2 is dramatically related to myeloid leukemia, and more studies are required for accurate connection with myeloma diseases and this area.
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